Sanguinarine (Pseudochelerythrine) Is a Potent Inhibitor of NF-κB Activation, IκBα Phosphorylation, and Degradation
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چکیده
منابع مشابه
Natural Germacrane Sesquiterpenes Inhibit Osteoclast Formation, Bone Resorption, RANKL-Induced NF-κB Activation, and IκBα Degradation.
Osteolytic bone diseases are commonly presented with enhanced osteoclast formation and bone resorption. Sesquiterpene lactone natural compounds have been found to possess anti-inflammatory and immune-modulation effects. Here, we identified three germacrane sesquiterpenes using computer-based virtual screening for the structural similarity with sesquiterpene lactone, parthenolide. We showed that...
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Each of the IkB proteins contains six or more 33The inhibitory protein, IkBa, sequesters the transcripresidue-long ankyrin repeats, named for their homology tion factor, NF-kB, as an inactive complex in the cytoto repeats in the erythrocyte protein ankyrin (reviewed plasm. The structure of the IkBa ankyrin repeat domain, in Bork, 1993). Ankyrin, which has 24 such repeats, links bound to a parti...
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The NF-κB pathway is regulated by SUMOylation at least at three levels: the inhibitory molecule IκBα, the IKK subunit γ/NEMO and the p52 precursor p100. Here we investigate the role of SUMO-2/3 in the degradation of IκBα and activation of NF-κB mediated by TNFα. We found that under conditions of deficient SUMOylation, an important delay in both TNFα-mediated proteolysis of IκBα and NF-κB depend...
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The NF-κB pathway is regulated by multiple post-translational modifications including phosphorylation, ubiquitylation and SUMOylation. Many of these modifications act on the natural inhibitor IκBα modulating its capacity to control signal-mediated NF-κB activity. While the canonical pathway involving the phosphorylation and polyubiquitylation of IκBα has been well characterized, the role of the...
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main of approximately 100 amino acids in length. All IkBa regulates the transcription factor NF-kB through dimerization contacts are mediated through this second the formation of stable IkBa/NF-kB complexes. Prior domain, referred to as the dimerization domain. The to induction, IkBa retains NF-kB in the cytoplasm until carboxy-terminal 13 amino acids (NLS polypeptide), the the NF-kB activation...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.48.30129